Registration Dossier
Registration Dossier
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EC number: 948-071-5 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
- Justification for type of information:
- Water solubility could not be determined due to micelle formation in aqueous test solution.
Critical micelle concentrations were determined as follows:
pH 5: 526 µg/mL
pH 7: 363 µg/mL
pH 9: 367 µg/mL - Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The aqueous solubility could not be determined because the test substance has surface-active properties that will display interfacial properties in aqueous media. The test substance has been demonstrated to form micelles in aqueous solutions. Solubility of the test substance was confirmed through a combination of turbidity and critical micelle concentration measurements, but these results are not considered quantitative.
- Qualifier:
- according to guideline
- Guideline:
- other: (Q)SAR
- Version / remarks:
- EPI Suite v 4.11
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: (Q)SAR
- Key result
- Water solubility:
- 28.04 mg/L
- Conc. based on:
- test mat.
- Remarks:
- Neutral alkyl amine
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: (Q)SAR
- Conclusions:
- The aqueous solubility could not be determined because the test substance has surface-active properties that will display interfacial properties in aqueous media. The test substance has been demonstrated to form micelles in aqueous solutions. Solubility of the test substance was confirmed through a combination of turbidity and critical micelle concentration measurements, but these results are not considered quantitative.
Additional water solubility testing is waived based on the surface-active properties of the test substance and the inherent difficulty in testing surface-active substances.
Referenceopen allclose all
Description of key information
Waiver and (Q)SAR
Water solubility could not be determined due to micelle formation in aqueous test solution.
Critical micelle concentrations were determined as follows:
pH 5: 526 µg/mL
pH 7: 363 µg/mL
pH 9: 367 µg/mL
The aqueous solubility could not be determined because the test substance has surface-active properties that will display interfacial properties in aqueous media. The test substance has been demonstrated to form micelles in aqueous solutions. Solubility of the test substance was confirmed through a combination of turbidity and critical micelle concentration measurements, but these results are not considered quantitative.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
