Reaction products of stearic acid with 2-aminoethanol, maleic anhydride and sodium sulphite

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-10-03 / 2018-03-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

0.257 g/L

Conc. based on:

test mat.

Incubation duration:

>= 288 - <= 336 h

Temp.:

20 °C

pH:

>= 6.2 - <= 6.3

Remarks on result:

other: calculations were based on the quantitative analysis of the constituent Disodium C-(2-((1-oxooctadecyl)amino)ethyl) sulphonato-succinate (CAS RN 85081-55-6) (m/z 506.4)

Preliminary Test

The content of test item dissolved in the water sample was 0.115 g/L.

Main Study

The results for the samples taken at 288, 312 and 336 hours are given in the table below. The maximum difference of the concentrations determined in the 288, 312 and 336 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations. A small response at the retention time of the test item was detected in the sample from the blank water mixture diluted in a 1:4 (v:v) ratio with tetrahydrofuran. This was probably caused by carry-over and as no impact on the outcome of the study. The concentration could not be calculated due to the cut off of the calibration curve.

Stirring time [hours]	Analyzed concentration [g/L]	Mean [g/L]	Maximum difference [%]	pH
288	0.259	0.257	5.7	6.3
312	0.248			6.3
336	0.263			6.2

Conclusions:

The water solubility of the test item at 20°C was 0.257 g/L.

Executive summary:

The flask method was applied for the determination of the water solubility of the test item according to OECD Guideline 105 and EU Method A.6. The water solubility of the test item at 20°C was 0.257 g/L. The pH of the aqueous samples was 6.2 and 6.3.

Description of key information

The flask method was applied for the determination of the water solubility of the test item according to OECD Guideline 105 and EU Method A.6. The water solubility of the test item at 20°C was 0.257 g/L. The pH of the aqueous samples was 6.2 and 6.3.

Key value for chemical safety assessment

Water solubility:

0.257 g/L

at the temperature of:

20 °C

Additional information

One reliable experimental study is available and is selected as key study (Charles River, 2018). It was performed according to OECD Guideline 105 and EU Method A.6, and under GLP principles.