Registration Dossier
Registration Dossier
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EC number: 619-946-6 | CAS number: 890707-29-6
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2009 - July 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
Test material
- Reference substance name:
- 2-Amino-5-cyano-N,3-dimethylbenzamide
- Cas Number:
- 890707-29-6
- Molecular formula:
- C10H11N3O
- IUPAC Name:
- 2-Amino-5-cyano-N,3-dimethylbenzamide
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Shimadzu Prominence High-Performance Liquid Chromatograph
- Type, material and dimension of analytical (guard) column: Cyanopropyl column, length 250 mm × 4.6 mm id × 5 μm particle size
- Detection system: UV
MOBILE PHASES
- Type: methanol/water, 55:45 (v/v).
- Experiments with additives carried out on separate columns: no
DETERMINATION OF DEAD TIME
- Method: by inert substance, formamide, which is not retained by the column
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Aniline, Atrazine, Carbendazim, and Naphthalene
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k':
k' = t(R) - t(0) / t(0)
where
t(R) = HPLC retention time of test and reference item (min)
t(0) = HPLC dead time (min)
- Determination of the log Koc value: The Koc is deduced from the k' using a calibration plot of log Koc versus log k' of the reference items.
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Type:
- Koc
- Value:
- > 32.18 - <= 33.32 dimensionless
- Key result
- Type:
- log Koc
- Value:
- 1.52 dimensionless
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
- Details of fitted regression line (log k' vs. log Koc):
log Koc
- Graph of regression line attached
- Average retention data for test substance:
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The Koc value for IN-L8E22 was 32.75 ± 0.57 (log Koc = 1.52).
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