Registration Dossier
Registration Dossier
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EC number: 606-661-7 | CAS number: 208709-55-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
For this endpoint information from a structural similar compound is available. The study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 421. See chapter 13 report for a more detailed justification.
Link to relevant study records
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For this endpoint information from a structural similar compound is available. The study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 421.
See chapter 13 report for a more detailed justification. - Reason / purpose for cross-reference:
- read-across source
- Clinical signs:
- effects observed, treatment-related
- Reproductive function: oestrous cycle:
- no effects observed
- Dose descriptor:
- NOAEL
- Effect level:
- 225 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- Critical effects observed:
- no
- Clinical signs:
- no effects observed
- Dose descriptor:
- NOEL
- Generation:
- F1
- Effect level:
- 225 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- Critical effects observed:
- no
- Reproductive effects observed:
- no
- Conclusions:
- For this endpoint information from a structural similar compound is available. The study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 421.
See chapter 13 report for a more detailed justification.
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 225 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No classification and labelling is warranted for the reproduction parameters.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
