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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Hazard for air

Hazard for terrestrial organisms

Hazard for predators

Additional information

Conclusion on classification

Classification according directive 2008/1272/EEC (CLP)

Classification according directive 2008/1272/EEC (CLP) is performed independently for acute and chronic hazards.

Actute hazard category:

The highest acute aquatic toxicity of three trophic levels was determined for the freshwater green alga Desmodesmus subspicatus with an EC50 (72 h; growth rate) for Read across susbtance C16 DMA of 9.9 µg/L. Due to the difficult substance properties of DMA the study was performed in natural river water. Sometimes mitigating effects are observed for river water tests compared to tests involving synthetic water. This was not the case for results on algal toxicity of DMA. Where reliable studies for both test types are available for comparison (C10 DMA, C16 DMA) effect concentrations observed in the river water test were even lower than those determined using synthetic dilution water. Therefore, a mitigating factor is not required. The algal EC50 (72 h; growth rate) to be used for classification is therefore 10 µg/L.

This results in the following acute classification:

Category Acute 1, H400: Very toxic to aquatic life

M-factor: 100

 

Chronic hazard category:

Using available acute data, decisive for a possible chronic classification is failure or fulfillment of (1) rapid degradability and / or (2) presence or absence of a bioaccumulation potential.

BCF fish were estimated using the Arnot & Gobas (2003) ADME model. The highest calculated value for the DMA Category members is 223 L/kg and this value is below the CLP criteria of 500. This means the DMAs are regarded as non-bioaccumulative.

Rapid biodegradability according to CLP is given for substances which were assessed as “readily biodegradable” in screening studies (OECD 301). This is met by DMA category members.

Under these circumstances, no chronic classification results for DMA category members from the available acute data on ecotoxicity.

Using available chronic data (algae, invertebrates): The lowest chronic (no) effect concentration of the two trophic levels with chronic data available was determined for the freshwater green algaDesmodesmus subspicatus: An EC10 (72 h; growth rate) of 2.56 µg/L was determined for C16 DMA. Due to the difficult substance properties of DMA category members the study was performed in natural river water. Sometimes mitigating effects are observed for river water tests compared to tests involving synthetic water. This was not the case for results on algal toxicity of DMA. Where reliable studies for both test types are available for comparison (C10 DMA, C16 DMA) effect concentrations observed in the river water test were even lower than those determined using synthetic dilution water. Therefore, a mitigating factor is not required. The algal EC10 (72 h, growth rate) to be used for classification is therefore 2.6 µg/L.

This results in the following chronic classification, taking into account ready biodegradability:

Category Chronic 1, H410: Very toxic to aquatic life with long lasting effects

M-factor: 1