Registration Dossier
Registration Dossier
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EC number: 700-421-6 | CAS number: 1215122-81-8
Endpoint summary
Administrative data
Description of key information
Oral:
-rat, LD50 (C12DMA): 1220 mg/kg (male)
-rat, LD50 (C12DMA): 1890 mg/kg (male); 1450 mg/kg (female)
-rat, LD50 (C14DMA): >1600 mg/kg (male); 1320 mg/kg (female)
-rat, LD50 (C14DMA): 2166 mg/kg (male/female)
-rat, LD50 (C16DMA): 1015 mg/kg (male/female)
-rat, LD50 (C16DMA): 2000 mg/kg (male); >2000 mg/kg (female)
-rat, LD50 (C12-14DMA): >2000 mg/kg (male); 1015 mg/kg (female)
-rat, LD50 (C12-18DMA): 1500 mg/kg (male); 1300 mg/kg (female)
-rat, LD50 (C12-18DMA): >2000 mg/kg (male/female)
-rat, LD50 (C12-18DMA): 1000-1250 mg/kg (male/female)
-rat, LD50 (C18DMA): 2116 mg/kg (male/female)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no experimental data on acute toxicity for the registration substance N,N-dimethyl-C12-16-(even numbered)-alkyl-1-amines, lactates. The acute toxicity of the registration substance is derived from the available data of dimethyl alkylamines (DMAs) with comparable length of alkyl chain (source substances).
No acute toxicity potential was derived some aucte oral studies in rats with C14DMA, C16DMA, C18DMA, C12-18DMA and C12 -14 DMA (LD50 > 2000 mg/kg). However, in other studies of C12DMA, C14DMA, C16DMA and C12 -18DMA there is data indicating the LD50 is in the range of 1000 -1890 mg/kg.
Considering all the information available, the LD50 of the registration substance is considered to be greater than 1000 mg/kg. Therefore, the registration substance is classified as Cat.4 for acute oral toxicity,according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Justification for classification or non-classification
Based on the available data, the substance is classified as Cat.4 for acute oral toxicity,according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
