Octadecanedioic acid, 1,18-dimethyl ester

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

< 0 g/L

Conc. based on:

test mat.

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

>= 6.19 - <= 6.43

The preliminary test gave a result of less than 6.16 x 10-7 g/L which, according to the relevant test guidelines, means that the definitive test should be performed using the column elution method. However, the flask method was used instead for the following reasons. There were practical concerns when considering the column elution method, namely that the analysis procedure required large volumes of sample for extraction. As the column elution method requires a reservoir from which multiple samples are taken, the total volume of this reservoir would need to be so large as to make testing impractical using this method; this being compared to the flask method where there is no requirement for many samples to be taken from each system. Finally, as the test item is an ester, there was also some concern over the stability of the test item in aqueous solution over the longer periods required for the column elution compared to the flask method. For these reasons it was considered acceptable to use the flask method for the definitive testing rather than the column elution method.

On completion of the equilibration period, the samples were clear and colorless with excess test item present at the bottom and on the surface of the water in the test vessels. The solutions were decanted, avoiding excess test item and filtered and the supernatant was taken for analysis. The supernatant was visually observed to be clear/colorless and free from un-dissolved test item.

As no test item was detected in the samples the limit value calculated was used as the upper limit of water solubility.

Conclusions:

The water solubility of the test material was assessed according to OECD Guideline 105 and determined to be less than 6.16 x 10-7 g/L at 20 ± 0.5 ºC.

Executive summary:

The water solubility of the test substance was determined to be less than 6.16 x 10-7 g/L at 20 ± 0.5 ºC, using the flask method, designed to be compatible with method A6 water solubility of commission regulation (EC) No 440/2008 of 30 May 2008 and method 105 of the OECD guidelines for testing of chemicals, 27 July 1995 (Harlan Laboratories Ltd, 2013).

Description of key information

The water solubility of the test material was assessed according to OECD Guideline 105 and determined to be less than 6.16 x 10^-7 g/L at 20 ± 0.5 ºC.

Key value for chemical safety assessment

Water solubility:

0 g/L

at the temperature of:

20 °C

Additional information

As no test item was detected in the samples the limit value calculated was used as the upper limit of water solubility.

 

The water solubility of the test substance was determined to be less than 6.16 x 10-7 g/L at 20 ± 0.5 ºC, using the flask method, designed to be compatible with method A6 water solubility of commission regulation (EC) No 440/2008 of 30 May 2008 and method 105 of the OECD guidelines for testing of chemicals, 27 July 1995 (Harlan Laboratories Ltd, 2013).