Registration Dossier
Registration Dossier
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EC number: 306-522-8 | CAS number: 97281-23-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No short term toxic effects to fish up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity to fish of fatty acids, C16-18, 2-hydroxyethyl ester, (CAS 97281-23-7) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across was conducted to structurally related substances (CAS 627-83-8 and CAS 68583-51-7).
The study with the read-across substance ethylene distearate (CAS 627-83-8), was performed according to the OECD 203 (GLP) with the rainbow trout (Oncorhynchus mykiss) as test organism (Wetton, 1996). The test was conducted as limit test under semi-static conditions. No effects were observed after 96 h resulting in a LC50 of > 0.3 mg/L (nominal). 0.3 mg/L was the highest concentration which was soluble in the solubiliser tetrahydrofuran without precipitation.
The second read across study with decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) was performed according to EU Method C.1 under GLP compliance with the zebrafish Danio rerio (Cremer, 1995). The test was conducted under semi-static conditions as limit test with a Water Accommodated Fraction (WAF) of 1000 mg/L. The analytical determination of the test substance based on TOC-analysis resulted in different values since the test solutions were determined to be oversaturated, hence the nominal result is used as key value. No effects were observed during an exposure of 96 h. Therefore a LL50 > 1000 mg/L (nominal test mat. WAF) is used for the further assessment.
Based on the results from the structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), which are characterized by a similar ecotoxicological profile, it can be concluded that the fatty acids, C16-18, 2-hydroxyethyl esters, (CAS 97281-23-7) will not exhibit acute effects to fish up to the limit of water solubility.
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