Registration Dossier
Registration Dossier
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EC number: 306-522-8 | CAS number: 97281-23-7
Endpoint summary
Administrative data
Description of key information
Additional information
Fatty acids, C16-18, 2-hydroxyethyl ester, (CAS 97281-23-7) will not exhibit effects to aquatic organisms up to the limit of water solubility. For the assessment of fatty acids, C16-18, 2-hydroxyethyl ester, (CAS 97281-23-7) a read-across approach was chosen, based on data from similar fatty acid esters.
Justification for the analogue approach (read-across)
Fatty acid esters are generally produced by chemical reaction of an alcohol with an organic acid in the presence of an acid catalyst (Radzi et al., 2005). The esterification reaction is started by a transfer of a proton from the acid catalyst to the acid to form an alkyloxonium ion. The acid is protonated on its carbonyl oxygen followed by a nucleophilic addition of a molecule of the alcohol to a carbonyl carbon of acid. An intermediate product is formed. This intermediate product loses a water molecule and a proton to give an ester (Liu et al, 2006; Lilja et al., 2005; Gubicza et al., 2000; Zhao, 2000).
The available information on ecotoxicological properties of the glycol esters source and target substances show that no effects up to the limit of water solubility occurred. Moreover, all source and target substances are readily biodegradable and show a similar pattern in environmental distribution and behaviour characterised by low water solubility, high log Kow and log Koc.
Glycol esters have a common metabolic fate that involves a stepwise hydrolysis of the esterbonds by gastrointestinal enzymes by which the breakdown of glycol esters results in structurally similar chemicals, the fatty acid component and the respective alcohol (Long, 1958; Lehninger, 1970; Mattson and Volpenhein, 1972). Following hydrolysis of the ester bond, the breakdown product will be absorbed and metabolised. The toxicological properties show that all source and target substances have similar toxicokinetic behaviour and that the constant pattern consists in a lack of potency change of properties across the category, explained by the common metabolic fate of glycol esters independently of the fatty acid chain length and degree of glycol substitution
References:
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