Registration Dossier
Registration Dossier
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EC number: 268-793-8 | CAS number: 68140-41-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
In vitro skin corrosion study was conducted to evaluate the corrosivity potential of the test substance using the EpiDerm™ Human Skin Model after treatment periods of 3 and 60 minutes. Exposure period of 3 minutes gave 92.2% cell viability, after 60 minutes gave 91.1% cell viability. Therefore, test item was considered to be non-corrosive to the skin.
Further study was conducted in accordance with the OECD guideline, 404, to determine its skin irritation potential of the test substance. Albino rats were exposed to test substance for 4 hours and dermal irritation readings for erythema and oedema were performed approximately 4.5, 24, 48, 72 and 168 hours after treatment. There were minor skin irritation reactions in all of the test subjects. The maximum skin irritation score was 2 for erythema and 1 for oedema at the 72 hour observation. The mean value for erythema was 1.89 and oedema was 0.67 in the 3 animals from grading’s at 24, 48 and 72 hours after patch removal. Therefore, in accordance with the CLP guidance, the test substance does not meet the classification criteria for Skin irritation.
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