Registration Dossier
Registration Dossier
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EC number: 268-793-8 | CAS number: 68140-41-0
Endpoint summary
Administrative data
Description of key information
Acute Toxicity: Oral - The LD50 is > 2000 mg/kg body weight based on an OECD testguideline 420 compliant study, conducted under GLP conditions.
Acute Toxicity Dermal - This study is not required as the oral LD50 is > 2000 mg/kg body
Acute Toxicity Inhalaltion - This study is not required at the registered tonnage band.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The key study followed OECD testguideline 420 and was conducted under GLP conditions. This study has been assigned a klimisch rating of 1 as described by Klimisch (1997)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
Introduction
The study was performed to assess the acute oral toxicity of the test item in the Wistar strain rat.
Methods
Following a sighting test at a dose level of 2000 mg/kg, an additional four fasted female animals were given a single oral dose of test item, as a solution in dimethyl sulfoxide, at a dose level of 2000 mg/kg body weight. Clinical signs and body weight development were monitored during the study. All animals were subjected to gross necropsy.
Results
Mortality. There were no deaths.
Clinical Observations. There were no signs of systemic toxicity.
Body Weight. All animals showed expected gains in body weight.
Necropsy. No abnormalities were noted at necropsy.
Conclusion
The acute oral median lethal dose (LD50) of the test item in the female Wistar strain rat was estimated to be greater than 2000 mg/kg body weight (Globally Harmonized Classification System-Unclassified
Justification for classification or non-classification
Under the criteria set forth in the Classification, Labelling and Packaging Regulation (EC 1972/2008) the test substance is not classified for acute toxicity.
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