Registration Dossier
Registration Dossier
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EC number: 233-215-5 | CAS number: 10081-67-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Discussions on bioaccumulation potential
Key value for chemical safety assessment
- BCF (aquatic species):
- 1 245 L/kg ww
Additional information
The substance has been demonstrated to have a very high partition coefficient value which demonstrates that the potential for this substance to accumulate biologically is limited, given that it is a high value of log P = 7.90 ± 1.22 (25°C, pH = 6.9). The high log Pow is considered to be more a consequence of poor water solubility issues than a lipophilic tendency and is considered to be not indicative of the tendency to bioaccumulate in lipid tissues of aquatic organisms. This is based on literature data which demonstrates a tendency for the Bioconcentration Factor (BCF) to decrease as Log Pow increases above 6. At a high value of 7.9, the substance is proposed not to bioaccumulate. This is further confirmed via the use of the following QSAR tools:
· CAESAR BCF Read-Across (version 1.0.0)
· US EPA On-Line EPI Suite™v3.01 model BCFBAF
Which indicates that the substance is unlikely to bioaccumulate, with calculated values as follows:
BCF value (L/kg wet-wt) | Log BCF value | |
BCF Read-Across (version 1.0.0) | 888 | 2.95 |
US EPA On-Line EPI Suite™v3-01 model BCFBAF | 1245 | 3.095 |
This QSAR prediction is supported by a radiolabelled toxicokinetic study on the substance. Within this study,14C radiolabelled test material was not extensively distributed into tissues of rats after an oral dose. The substance did not demonstrate high absorption from the gastrointestinal tract. And after 72h, the concentrations in the majority of tissues had decreased significantly. The above factors indicate that bioaccumulation within body tissues is unlikely.
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