Registration Dossier
Registration Dossier
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EC number: 223-861-6 | CAS number: 4098-71-9
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Reference
Description of key information
Testing Toxicity to birds has been judged to be not necessary in accordance with column 2 of REACH Annex X.
There are no results from long-term bird or mammal studies reporting on dietary or oral exposure available. Hence a determination of the PNEC oral is not possible. However, considering that direct or indirect exposure of the soil compartment is unlikely and that hydrolysis is the dominating degradation process in the aquatic environment (no bioaccumulation) secondary poisoning is not determined to be a relevant exposure route for 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate.
Key value for chemical safety assessment
Additional information
The risk for secondary poisoning is negligible because the substance is predisposed to rapid hydrolysis. The degradation products are either characterized by a low potential for bioaccumulation; isophorone diamine has a log Kow of 0.99; or by a low potential to cross biological membranes, polyurea molecules are unlikely to cross biological membranes due to its relatively large molecular size. The absence of systemic bioavailability is also demonstrated in (eco-) toxicity studies with diisocyanates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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