Registration Dossier
Registration Dossier
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EC number: 215-685-3 | CAS number: 1344-01-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation potential of the registered substance was determined based on an assessment of the toxicokinetics of the substance. The substance is not expected to bioaccumulate.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The bioaccumulation potential of the registered substance was determined via an assessment of the toxicokinetics of the substance. The substance is sparingly soluble in water and this limits its bioavailability. However, in water it will exist in ionised form and any toxicity and metabolic activity needs to be considered with regard to the metal ions aluminium, calcium and sodium and in regard to silicates. The absence of specific toxicokinetic data from animal testing on the anhydride means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolism or excretion. However, there is sufficient evidence from the fact that the ions will probably by absorbed from ingestion and excreted in the urine. With the exception of aluminium, the ions present are essential for healthy living and are required as part of a healthy diet. There is no suggestion that the ions will accumulate in the body and research on aluminium entering the brain is considered invalid in view of the expected levels of exposure. The substance is not expected to bioaccumulate based on the results of the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
