Silicic acid, aluminum calcium sodium salt

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study was conducted by GLP compliant laboratory using OECD Testing Guideline 401.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

yes

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Silicic acid, aluminium, calcium, sodium salt

IUPAC Name:

Silicic acid, aluminium, calcium, sodium salt

Constituent 2

Reference substance name:

Silicic acid, aluminum calcium sodium salt

EC Number:

215-685-3

EC Name:

Silicic acid, aluminum calcium sodium salt

Cas Number:

1344-01-0

Molecular formula:

3.0-3.9 SiO2 . Al2O3 . 0.4-0.6 CaO . 0.4-0.6 Na2O . nH2O

IUPAC Name:

aluminium(3+) calcium sodium tris(oxosilanebis(olate))

Test material form:

other: solid

Details on test material:

Physical state: solid

Test animals

Species:

mouse

Strain:

other: ddY-N

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

Exposure period of 14 days

Doses:

1160, 1380, 1660 and 2000 mg/kg body weight

No. of animals per sex per dose:

5

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality was observed.

Clinical signs:

other: The excretion of the soft and caddy stool movement and pollution of the cover hair were observed in 1-3 cases after the dosage, but, as for the constant tendency, it was admitted that male and female in the degree of the outbreak situation and the symptom

Gross pathology:

As a result of killing all mice at the time of the examination end, and having held an autopsy by eye, the abnormality was not accepted by a main organ.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral lethal dose (LD50) of the test material in mice was found to be >2000 mg/kg bodyweight.

Executive summary:

The acute oral toxicity of the substance was determined in accordance with the OECD Guideline for Testing of Chemicals 401. The acute oral lethal dose (LD₅₀) of the test material in mouse was found to be >2000 mg/kg bodyweight. The substance is therefore not classified as an acute oral toxin according to EU CLP criteria.