Registration Dossier
Registration Dossier
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EC number: 203-012-6 | CAS number: 102-19-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard OECD test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.08
- Temp.:
- 25 °C
- Remarks on result:
- other: other details not available
- Conclusions:
- The octanol water partition coefficent of test chemical was determined to be 4.08 by HPLC method.
- Executive summary:
The octanol water partition coefficent of test chemical was determined according to OECD guideline no 117 using reverse phase HPLC method. In this method reference substances used were namely Butanone, Benzene, Biphenyl, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Allyl phenyl ether having log Pow between range 0.3 -4.6 and calibration graph was prepared and by using this graph, the octanol water partition coefficent of test chemical was determined to be 4.08.
Reference
| Test substance | K | log K | log Pow by generalized calibration curve | Mean of log Pow± S.D | |
| tR1 | 3.14 | 2.339 | 0.369 | 4.084 | 4.082 ± 0.003 |
| tR2 | 3.136 | 2.334 | 0.368 | 4.08 | |
Description of key information
The octanol water partition coefficient of test chemical was determined according to OECD guideline no 117 using reverse phase HPLC method. In this method reference substances used were namely Butanone, Benzene, Biphenyl, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Allyl phenyl ether having log Pow between range 0.3 -4.6 and calibration graph was prepared. By using this graph, the octanol water partition coefficient of test chemical was determined to be 4.08.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.08
- at the temperature of:
- 25 °C
Additional information
The octanol water partition coefficient of test chemical was determined according to OECD guideline no 117 using reverse phase HPLC method. In this method reference substances used were namely Butanone, Benzene, Biphenyl, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Allyl phenyl ether having log Pow between range 0.3 -4.6 and calibration graph was prepared. By using this graph, the octanol water partition coefficient of test chemical was determined to be 4.08.
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