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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The FEMA GRAS assessment of various flavor ingredients
Author:
T.B. Adams et. al.
Year:
2005
Bibliographic source:
Food and Chemical Toxicology, August 2005
Reference Type:
publication
Title:
Fragrance raw material monograph for the test chemical
Author:
D. L. J. Opdyke
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology,1978
Reference Type:
publication
Title:
WHO Food Additive Series evaluation of various flavors
Author:
World Health Organization
Year:
2017
Bibliographic source:
JECFA Food Additives Series ,2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
GLP compliance:
no
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopentyl phenylacetate
EC Number:
203-012-6
EC Name:
Isopentyl phenylacetate
Cas Number:
102-19-2
Molecular formula:
C13H18O2
IUPAC Name:
isopentyl phenylacetate
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Isoamyl Phenylacetate
- Molecular formula : C13H18O2
- Molecular weight : 206.283 g/mol

- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rats at dose 5000 mg/kg bw
Mortality:
No mortality was observed in treated rats at dose 5000 mg/kg bw
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be >5000 mg/kg bw,when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was done in rats using test chemical.No mortality was observed at dose 5000 mg/kg bw. Hence,LD50 value was considered to be >5000 mg/kg bw,when rats were treated with test chemical orally.