Registration Dossier
Registration Dossier
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EC number: 436-010-0 | CAS number: 422278-61-3 PRIMID V40-32
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 13th to June 22nd, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 50.8 g/L
- Temp.:
- 20 °C
- pH:
- ca. 7.3
- Details on results:
- Water solubility was not corrected for the purity of test item. Tables with detailed resultws are attached as illustration.
- Conclusions:
- Interpretation of results: very soluble (> 10000 mg/L)
The water solubility of the substance was determined to be 50.8 g/L (standard deviation ± 1.53 g/l). - Executive summary:
The determination of the water solubility of the substance was peformed according to OECD guideline No. 105, using the shake flask method. The saturation concentration at room temperature was estimated by a simplified flask method in a preliminary test to be higher than 10 mg/L. Therefore, the flask shaking was performed. Concentrations were determined after a shaking time of 24, 48 and 72 hours respectively at 30 °C. Afterwards the samples were equilibrated for 24 hours at 20 ± 5 °C. The measured results differ by less than 15%, therefore the study is considered to be valid. The substance was found to be extremely soluble, the mean value of 6 measurements (2 per shaking time) was 50.8 g/L.
Reference
Description of key information
In a OECD TG 105 study using shake flask method, water solubility of the substance was determined to be 50.8 g/L at 20 °C
Key value for chemical safety assessment
- Water solubility:
- 50.8 g/L
- at the temperature of:
- 20 °C
Additional information
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