Registration Dossier
Registration Dossier
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EC number: 404-986-7 | CAS number: 74227-35-3 BDS-HEXAFLUOROPHOSPHATE; BDS-HEXAFLUORPHOSPHAT; ESACURE 1004
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The bacterial reverse mutation assay and the in vitromammalian cell mutation assay showed clear negative results. Both of the studies identify the substance as non mutagenic.
Short description of key information:
In order to gain an understanding of the potential mutagenicity of the test item "A mixture of: thiobis(4,1-phenylene)-S,S,S',S'-tetraphenyldisulfonium bishexafluorophosphate; diphenyl(4-phenylthiophenyl)sulfonium hexafluorophosphate", the following studies were performed:
- A bacterial reverse mutation assay, according to OECD 471; this study was included in the Notification dossier of the first Notifier (1989); since under Directive 67/548/EEC the studies of the first notifier were not included in the dossier, Lamberti has the letter of Access, but not the complete study report. The study can be considered reliable since already evaluated by the Authority.
- An In vitro mammalian cell gene mutation test, according to OECD 476, performed under GLP
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
On the grounds of the entire genotoxicity assessment, it can be concluded that the substance is not characterized by genotoxic properties.
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