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Diss Factsheets
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EC number: 940-786-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Nov. 3, 1998-Nov. 19, 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study for read-across source substance (European commercial linear alkyl benzene (LAB), CAS No. 67774-74-7) done according to OECD guideline 204.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzene, C10-13-alkyl derivs.
- EC Number:
- 267-051-0
- EC Name:
- Benzene, C10-13-alkyl derivs.
- Cas Number:
- 67774-74-7
- IUPAC Name:
- undecylbenzene
- Reference substance name:
- Undecylbenzene
- EC Number:
- 229-806-2
- EC Name:
- Undecylbenzene
- Cas Number:
- 6742-54-7
- IUPAC Name:
- undecylbenzene
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling was done on test solutions on days 1 and 14 of the test. Samples were taken from the test solution both before treatment, and after 24 hrs of treatment.
Test solutions
- Details on test solutions:
- 1 g/L of LAB was added to reconstituted water; this was stirred for 24 hours and then transferred to a separatory funnel and allowed to stand 4 hours. The lower portion was slowly filtered (0.45 um HV Millipore) and used for testing and for dilutions (2:1 and 1:1).
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Source: YARA Tropical Fish
- Length at study initiation (length definition, mean, range and SD): 3 cm average
- Weight at study initiation (mean and range, SD): 0.27 g average
- Feeding during test
- Food type: Mangime SERA DISKUS
- Amount: 2% per initial fish weight
- Frequency: daily
ACCLIMATION
- Acclimation period: 14 days
- Health during acclimation (any mortality observed): no mortality after 1st 48 hrs
Study design
- Test type:
- semi-static
- Total exposure duration:
- 14 d
Test conditions
- Hardness:
- 246 mg/L CaCO3
- Test temperature:
- 24.2 degree C
- pH:
- 7.4
- Dissolved oxygen:
- 8.0 mg/L
- Nominal and measured concentrations:
- Mean measured concentration: before treatment (0 hrs) 5.53, 6.64, and 10.18 ug/L
after treatment (24 hrs) 0.43, 1.37, and 2.68 ug/L
Nominal concentration: 0, 5, 6.5, and 10 ug/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers
- Material, size, headspace, fill volume: 5 L
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates):
- Biomass loading rate: 0.54 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
- Ca/mg ratio: 4:1
OTHER TEST CONDITIONS
- Photoperiod: 16 hrs light/8 hrs dark
- Light intensity: artificial light
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Daily observations were made of swimming behaviour, reaction to stimuli, discoloration, food intake, and mortality. All fish were weighed and measured before the test. Survivors were weighed at test termination.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 10 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No effects were observed for the concentrations tested. Both the LOEC and NOEC were > 10 ug/L. A decrease in the test substance concentration was observed within 24 hours (day 1 and day 14), but the daily renewal of test solutions guaranteed the exposure to the test substance.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Body weight (mean)
Concentration
0 (ug/L)
5 (ug/L)
7.5 (ug/L)
10 (ug/L)
Initial (g)
0.20
0.4
0.20
0.28
Final (g)
0.20
0.41
0.21
0.28
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 14-day NOEC for fish was > 10 ug/L.
- Executive summary:
In cases where no data were available on the target substance, Benzene, C15 -16 -alkyl derivs., data were read across from a structurally related material (the test substance).
No study regarding toxicity to fish was available for benzene, C15 -16 -alkyl derivs.; however, a valid 14 -day study performed according to OECD guideline 204 determined the long-term toxicity to fish of the read-across source substance (European commercial linear alkyl benzene (LAB)) . Fish were exposed for 14 days to a water accommodated fraction of 0, 5, 6.5, and 10 ug/L of test substance. The test medium was renewed daily. Fish were monitored daily for toxicity during the study. No adverse effects were seen during the study period. The NOEC for fish is > 10 ug/L. The LC50 was > 10 ug/L/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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