Registration Dossier
Registration Dossier
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EC number: 411-700-4 | CAS number: 140921-24-0 HÄRTER VERSUCHSPRODUKT LS 2959E; HÄRTER VP LS 2959E
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The data are available from ECHA as data older than 12 years of age and no longer protected. The registrant has been unable to varify the quality of the original data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
- EC Number:
- 411-700-4
- EC Name:
- 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
- Cas Number:
- 140921-24-0
- Molecular formula:
- C32H62N4O6
- IUPAC Name:
- 2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 4h
- Observation period:
- 24, 48 and 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- No skin reactions observed.
Any other information on results incl. tables
Irritation parameter |
Basis |
Time point |
Score |
Max. score |
Reversibility |
Remarks |
erythema score |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
erythema score |
animal #2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
erythema score |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
erythema score |
|
|
|
0 |
|
Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals) |
edema score |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
edema score |
animal #2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
edema score |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
edema score |
|
|
|
0 |
|
Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals) |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not irritation to skin
- Executive summary:
The substance has been exposed to the skin of 3 New Zealand White rabbits. No skin reactions were observed and the substance is considered to be non irritation to skin.
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