Registration Dossier
Registration Dossier
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EC number: 219-145-8 | CAS number: 2372-82-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
- EC Number:
- 219-145-8
- EC Name:
- N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
- Cas Number:
- 2372-82-9
- Molecular formula:
- C18H41N3
- IUPAC Name:
- bis(3-aminopropyl)(dodecyl)amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw corresponding to 600 mg a.i./kg bw (undiluted test substance)
- No. of animals per sex per dose:
- 5 per sex per dose.
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 600 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: based on 30% purity
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the study conditions, the LD50 of the test substance in Sprague-Dawley rats was established at >600.0 mg a.i./kg bw. It must however be noted that the animals were sacrificed due to severe suffering linked to skin corrosion and that toxicity was not of systemic nature.
- Executive summary:
A study was conducted to determine the acute dermal toxicity of the test substance according to EU Method B.3, in compliance with GLP. Five rats per sex per dose were exposed to the test substance at a concentration of 2000 mg/kg bw (corresponding to 600 mg a.i./kg bw based on a purity of 30%). Under the study conditions, the LD50 of the test substance in Sprague Dawley rats was established at >600.0 mg a.i./kg bw. It must however be noted that the animals were sacrificed due to severe suffering linked to skin corrosion and that toxicity was not of systemic nature (Jones, 1989).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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