Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-chlorobutyryl chloride
- EC Number:
- 225-059-1
- EC Name:
- 4-chlorobutyryl chloride
- Cas Number:
- 4635-59-0
- Molecular formula:
- C4H6Cl2O
- IUPAC Name:
- 4-chlorobutanoyl chloride
- Details on test material:
- Name of the test substance used in the study report: gamma-Chlorbuttersäurechlorid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weights: males 25.7 g, females 22.3 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 50, 100, 125, 160, 200, 1600 ul/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 176 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 140 other: ul/kg
- Remarks on result:
- other: original value
- Mortality:
- 50 ul/kg: 0/10 after 7 days; 100 ul/kg: 3/10 after 7 days; 125 ul/kg: 3/10 after 7 days; 160 ul/kg: 8/10 after 7 days; 200 ul/kg: 10/10 after 7 days; 1600 ul/kg: 9/10 after 7 days
- Clinical signs:
- prone position, atonia, convulsions, dyspnea
- Gross pathology:
- obtuse angled liver borders
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
