Registration Dossier
Registration Dossier
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EC number: 223-445-4 | CAS number: 3896-11-5
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Well reported study, no details on test material purity
Data source
Reference
- Reference Type:
- publication
- Title:
- Estrogenic Activities of UV Stabilisers Used in Food Contact Plastics and Benzophenone Derivatives Tested by the Yeast Two-Hybrid Assay
- Author:
- Kawamura Y, Ogawa Y, Nishimura T, Kikuchi Y, Nishikawa J, Nishihara T, Tanamoto K
- Year:
- 2 003
- Bibliographic source:
- J. Health Sci., 49(3), 205-212
Materials and methods
- Principles of method if other than guideline:
- Estrogenic activity tested by the yeast two-hybrid assay
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Bumetrizole
- EC Number:
- 223-445-4
- EC Name:
- Bumetrizole
- Cas Number:
- 3896-11-5
- Molecular formula:
- C17 H18 Cl N3 O
- IUPAC Name:
- 2-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Supplier: Tokyo Kasei kogyo Co. (Tokyo, Japan)
Results and discussion
- Details on results:
- The REC10 was >1.0E-04 M, indicating that the test substance had no estrogenic activity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
