Fatty acids, C6-12, mixed tetraesters with heptanoic acid, pentaerythritol, 3,5,5-trimethylhexanoic acid and valeric acid

PBT assessment

PBT assessment: overall result

Reference

Name:

Hatcol 1189

Type of composition:

legal entity composition of the substance

State / form:

liquid

Reference substance:

Hatcol 1189

Reference substance:

Hatcol 1189

Reference substance:

Hatcol 1189

Reference substance:

Hatcol 1189

Reference substance:

Hatcol 1189

PBT status:

the substance is not PBT / vPvB

Justification:

Assessment of PBT / vPvB properties has been conducted in accordance with the guidance provided in Annex XIII of Regulation 1907/2006 (as amended by Commission Regulation No 253-2011 of 15 March 2011). The substance is not considered to be a PBT or a vPvB substance.

Persistence

The available data from the read across substances suggest ready biodegradability of the substance to be between 10 and 60% degradation. the substance is not readily biodegradation, not achieving the 10 day window expressed in OECD test guidelines, but there is significant partial degradation expected to occur in the environment. The substance is a UVCB substance and in reference to Annex I of the OECD Guideline for Testing of Chemicals ‘Revised introduction to the OECD guidelines for testing of chemicals, section 3’ (OECD, March 2006), the 10-day window should not be considered for this substance. Therefore, the substance is considered to be Readily biodegradable.

Bioaccumulation

Based on the available information from the read across substances, the substance is expected to have a high Kow value (9.18 at 20°C). In accordance with the screening criteria for bioaccumulation in the ECHA Guidance (Chapter R.11 PBT Assessment) the substance would screen as a potential bioaccumulative substance. The likely reliability of the log Kow is however, considered to diminish above a value of 6, as noted in Appendix R.11-1 Annex 1 of ECHA guidance on PBT assessment. Substances with log Kow between 4.5 and 6 are considered likely to be highly accumulating; however no substantial bioconcentration is assumed having a log Kow value greater than 6. For compounds having a log Kow greater than 6, a gradual decrease of BCF is observed and it has been hypothesised within the published literature that a high log Kow is more an effect of solubility than a tendency of the substance to be lipophilic.

This was coincided with the data from the read across substances; where QSAR assessment of C5, C9iso and C10 FA tetraesters using BCFBAF v3.01 resulted in a mean BCF value of 2.703L/kg ww

On the basis of this the substance is not considered to be bioaccumulative.

Toxicity

The substance is not considered to be toxic above the limit of solubility on the basis of the available ecotoxicity studies available from read across substances. All L(E)C50 data are determined to be in excess of water solubility. No toxicity to aquatic species was observed at or below the water solubility of the substance.

The available data determine that the substance is not mutagenic or clastogenic and is not classified as a reproductive toxin. No carcinogenicity studies have been conducted, however there is no evidence from the available information to suggest that the substance would be carcinogenic.

The repeat dose toxicity to mammals was determined to be >150 mg/kg/day and the substance is not classified to induce chronic toxicity on the basis of the available data.

The substance is not classified as carcinogenic, mutagenic or toxic to reproduction, causing chronic toxicity or specific target organ toxicity following repeated or prolonged exposure. The substance therefore does not meet the toxicity criterion.

Conclusions

In conclusion Reaction product of pentanoic acid, C6-C12 mixed fatty acids, pentaerythritol, heptanoic acid and 3,5,5-trimethylhexanoic acid CAS 156558-98-4 is not considered to be a PBT or vPvB substance.