Fatty acids, dehydrated castor-oil

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short abstract available. In the publication less than basic data is given.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

RANGE-FINDING TOXICITY DATA - List V

Author:

Smyth, H.F. Jr. et al.

Year:

1954

Bibliographic source:

AMA archives of industrial hygiene and occupational medicine, 10/501/51: 61 - 68

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Inhalation Risk Test, where animals were exposed for up to 8 h to a flowing stream of air approaching saturation with vapour until the period killing half of the animals within a 14 day recovery period is defined.

GLP compliance:

no

Test type:

other: Inhalation Risk Test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Hexanoic acid

EC Number:

205-550-7

EC Name:

Hexanoic acid

Cas Number:

142-62-1

IUPAC Name:

hexanoic acid

Details on test material:

- Name of test material (as cited in study report): hexanoic acid
- Analytical purity: no data

Test animals

Species:

rat

Strain:

other: albino rat, not further specified

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE
Source and rate of air: dried air
System of generating particulates/aerosols: The stream is prepared by passing dried air through a fritted disc gas washing bottle initially at room temperature.

Analytical verification of test atmosphere concentrations:

no

Remarks on duration:

different durations in a logarithmic series with a ratio of two up to 8 hours

Concentrations:

1.3682 mg/L (QSAR; Danish EPA Database, 2004; saturated vapour concentration at 20 °C).

No. of animals per sex per dose:

6 males

Control animals:

other: analogue tests with other substances were also reported

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 1.368 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: max. saturated vapour concentration

Mortality:

No mortality occurred in rats, which were exposed for 8 hours to a saturated vapour concentration.