Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Endpoint summary
Administrative data
Description of key information
The substance is a dermal sensitiser. There is no information regarding respiratory sensitisation. The substance does not have any potential of respiratory exposure to the worker due to its physical state and extremely low vapour pressure. Furthermore effective risk management measures and operational conditions are in place to avoid any contact with the substance.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The substance induced sensitisation in a guinea pig Maximization assay with ≥ 30 % responding at > 1 % intradermal induction dose, and so is classified as a dermal sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no information regarding respiratory sensitisation.
The substance is a waxy solid at room temperature, which does not form particles. The melting point of the substance is 29.6°C. Thus, the substance may not cause a respiratory exposure due to dust formation.
The substance has a vapour pressure of 0.037 Pa at 20 °C. This value corresponds to 0.000037 kPa at 20°C. In the ECHA guidance document R.14 the low volatility band is characterized with < 0.5 kPa. Based on this information it can be concluded that the substance is at the lower end of the low volatility band, i.e. the substance has an extremely low vapour pressure. Thus, relevant exposure of the substance due to the vapour pressure is not expected. Due to its skin sensitizing properties the substance is handled reducing/avoiding contact with the substance. The implemented risk management measures (RMMs) and operational conditions (OCs) ensure that the risk for the worker is adequately controlled. Pure CPSS 53 is exclusively used in industrial settings, in small amounts as UV stabilisers in plastic articles. Based on the fact that the substance is embedded within a matrix, no emission from the matrix is expected, therefore no exposure to professionals or the general population is expected.
Justification for classification or non-classification
The substance is classified as a dermal sensitiser category 1 according to Regulation EC (No.) 1272/2008. A sub-categorisation is not warranted due to ≥ 30 % responding at > 1 % intradermal induction dose with a high incidence of sensitised guinea pigs.
Risk management measures (such as gloves) will be recommended to minimize the risk of exposure to workers.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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