Registration Dossier
Registration Dossier
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EC number: 292-883-6 | CAS number: 91002-07-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- not stated
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Route of administration is not relevant for RA purposes.
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental studies on barium poisoning
- Author:
- Jaklinski, A. et al.
- Year:
- 1 967
- Bibliographic source:
- Journal of Forensic Medicine 14: 13-15
Materials and methods
- Type of study / information:
- Acute toxicity. injected intraperitonally(mice) and subcutaneously (rats)
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In this study BaCl2 was injected in mice and rats, and the LD50 value was determined. Also, the study was conducted in order to determine the influence of potassium on the course of acute intoxications with barium compounds. In addition, rabbits and rats were injected with BaCl2 in order to determine the effect of BaCl2 on the potassium level in the blood serum.
- GLP compliance:
- no
Test material
- Reference substance name:
- Barium chloride
- EC Number:
- 233-788-1
- EC Name:
- Barium chloride
- Cas Number:
- 10361-37-2
- IUPAC Name:
- barium dichloride
- Details on test material:
- - Name of test material (as cited in study report): Barium chloride (BaCl2)
No further significant information was stated.
Constituent 1
Results and discussion
Any other information on results incl. tables
LD50 (mice): 60.5 mg/kg
LD50 (rats): 27.5 mg/kg
Barium chloride (intraperitoneal dose of 20 mg/kg) 30 minutes after its injection into rats lowers the level of potassium from 17.6 mg per 100 ml. (the control level) to 11.9 mg per 100 ml. Barium chloride subcutaneously also causes a lowering of the potassium levels in the blood serum of rabbits.
Applicant's summary and conclusion
- Conclusions:
- LD50 (mice): 60.5 mg/kg
LD50 (rats): 27.5 mg/kg
Barium chloride (intraperitoneal dose of 20 mg/kg) 30 minutes after its injection into rats lowers the level of potassium from 17.6 mg per 100 ml. (the control level) to 11.9 mg per 100 ml. Barium chloride subcutaneously also causes a lowering of the potassium levels in the blood serum of rabbits.
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