Registration Dossier
Registration Dossier
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EC number: 247-952-5 | CAS number: 26741-53-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no data how the test substance was exposed (as dust, aerosol, ...), only 1 hour exposure
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- EC Number:
- 247-952-5
- EC Name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Cas Number:
- 26741-53-7
- Molecular formula:
- C33H50O6P2
- IUPAC Name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Details on test material:
- no further data provided
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Weston MDW-6140-077-01308-M
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: average: 225 g
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 3 days
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- The animals were exposed to the test material in a specially constructed, all plexiglas inhalation chamber which has a capacity of 355 cubic liters. Each animal was placed in a separate wire cage during exposure to prevent filtration of inspired air by animal fur. The test material(s) are generated into the test chamber atmosphere by various methods depending upon the nature of the test material. The average nominal sample concentration is calculated by dividing the total amount of test material used by the total volume of the chamber. The chamber is equipped with blowers so that after the test sample was introduced into the chamber's atmosphere the air was continually recirculated during the test period.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 2 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- All animals survived.
- Clinical signs:
- other: All animals appeared normal during the 14 day period.
- Gross pathology:
- Organs of the thorax and abdomen appeared normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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