3-methoxybutyl acetate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short summary of proprietary study available, contributing to weight of evidence.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1930

Materials and methods

Principles of method if other than guideline:

A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously to 1 guinea pig at a single dose of 0.1 g/kg and to another guinea pig, at the same dose, on 6 consecutive days (see 7.5.4). Rats were also dosed subcutaneously with a 10% solution of 3-methoxybutyl acetate in oil at a single dose of 0.5 g/kg and 1 g/kg.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-methoxybutyl acetate

EC Number:

224-644-9

EC Name:

3-methoxybutyl acetate

Cas Number:

4435-53-4

Molecular formula:

C7H14O3

IUPAC Name:

3-methoxybutyl acetate

Constituent 2

Reference substance name:

butoxyl

IUPAC Name:

butoxyl

Details on test material:

Name of test material (as cited in study report): 3-methoxy-1-butyl acetate

Test animals

Species:

other: guinea pig and rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data.

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

other: oil

Details on exposure:

A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously, as a single dose, to 1 guinea pig and to rats. No further details provided.

Doses:

0.1 g/kg - guinea pig; 0.5 or 1.0 g/kg - rats

No. of animals per sex per dose:

1 (rats not specified)

Control animals:

no

Details on study design:

no data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

other: No effect level

Effect level:

1 000 mg/kg bw

Remarks on result:

other: a single dose of 0.5 g/kg and 1 g/kg did not cause any symptoms in rats

Clinical signs:

No adverse clinical signs were seen.

Applicant's summary and conclusion

Conclusions:

A single subcutaneous injection of a 10% solution of 3-methoxybutyl acetatel in oil did not cause any adverse effects to a guinea pig (at a dose of 100 mg/kg) or to rats at a dose of 500 or 1000 mg/kg.

Executive summary:

A 10% solution of 3 -methoxybutyl acetate in oil was injected subcutaneously to a guinea pig at a dose of 100 mg/kg and to rats at a dose of 500 or 1000 mg/kg on a single occasion. There were no adverse clinical signs. 3 -Methoxybutyl acetate, as a 10% solution in oil, was of low toxicity to by the subcutaneous route to guinea pigs at a dose level of 100 mg/kg/day and to rats at 500 or 1000 mg/kg.