Registration Dossier
Registration Dossier
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EC number: 431-840-1 | CAS number: 87010-29-5 OXIPROPAZON; OXYPROPAZON
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study + GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- EC Number:
- 431-840-1
- EC Name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- Cas Number:
- 87010-29-5
- Molecular formula:
- C6 H11 N O3
- IUPAC Name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- Details on test material:
- - Name of test material (as cited in study report): 0xypropazone
- Physical state: Slightly yellowish, vlscous llquid
- Analytical purity: 96.5%
- Lot/batch No.: #120446 / 7.12.90
- Stability under test conditions: Stability is guaranteed throughout the experimental period
- Storage condition of test material: The test material was kept in a closed container at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bor:WISW (SPF-Cpb)
- Age at study initiation: Males 8 weeks, females 9 weeks
- Weight at study initiation: Males 176-197, females 147-159 g
- Housing: Macrolon cages, type II, one animal per cage
- Diet: Standard diet ad libitun, ssniff R, Special diet for rats
- Water: ad libitum
- Acclimatization: Animals were kept at least five days under test conditions before administration
- Fasting period before study: approximately 16 h
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 50-65
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Desalted water
MAXIMUM DOSE VOLUME APPLIED: 21.5 ml - Doses:
- 5110 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 16 days
- Frequency of observations and weighing: once daily observation, weighing on day 0, 7 and 14
- Necropsy of survivors performed: yes (gross necroscopy)
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 110 mg/kg bw
- Mortality:
- Male: 5110 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5110 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: slight Hypokinesia, restrained gait, sunken sides, and piloerection.
Symptoms were recorded in all animals and were present beween 30 minutes and two days after treatment. - Body weight:
- see table below
- Gross pathology:
- Effects on organs:
No alterations were detected.
Any other information on results incl. tables
Dose |
Animal No |
Day 0 |
Day 7 |
Day 14 |
5110 |
1 |
181 |
234 |
284 |
5110 |
2 |
186 |
225 |
256 |
5110 |
3 |
197 |
243 |
284 |
5110 |
4 |
176 |
225 |
261 |
5110 |
5 |
179 |
215 |
246 |
5110 |
6 |
156 |
182 |
195 |
5110 |
7 |
159 |
184 |
191 |
5110 |
8 |
147- |
171 |
179 |
5110 |
9 |
158 |
193 |
194 |
5110 |
10 |
155 |
181 |
185 |
Body weights [g]
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
