Registration Dossier
Registration Dossier
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EC number: 236-291-8 | CAS number: 13282-70-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-02-05 to 2015-05-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- EC Method A.8; OECD Method 117
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- EC Method A.8
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 6
- Temp.:
- 25 °C
- pH:
- 10
- Details on results:
- The test substance was determined to have a retention time longer than that of the highest standard, DDT, which has a known log10Pow value of 6.2, only eluting after the mobile phase strength was increased to 100% methanol. A log10Pow value of greater than 6 was thus indicated, equivalent to a Pow value of greater than 10^6.
- Conclusions:
- The substance was determined to have a log10Pow value of greater than 6, equivalent to a Pow value of greater than 10^6.
- Executive summary:
The study was performed to determine the n-octanol/water partition coefficient of the test substance. The study was designed in accordance with accepted principles in order to meet the requirements of REACH Regulation (EU) No 1907/2006 of the European Parliament and of the Council.
The method followed is amongst those described in Commission Regulation (EC) No. 440/2008 (Method A.8) and the OECD Guidelines for the Testing of Chemicals (Method 117).
As the test substance contains an amine functional group, the test was performed at pH 10.The substance was determined to have a log10Pow value of greater than 6, equivalent to a Pow value of greater than 106.
Reference
Calculations:
The partition coefficient is deduced from the capacity factor, k, given by
k = (tr - to) / to
where tr is the measured retention time of sample or reference and to is the retention time of the internal deadtime standard.
A calibration plot of log10k versus log10Pow is constructed for the reference standards. The logarithm of the capacity factor for the test substance is then calculated and the log10Pow value is determined by interpolation, if appropriate.
Description of key information
The substance was determined to have a log10Pow value of greater than 6, equivalent to a Pow value of greater than 106.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.2
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
