Registration Dossier
Registration Dossier
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EC number: 604-759-4 | CAS number: 150928-21-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 29 Dec 1992
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted 30 Mar 1989
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
- EC Number:
- 604-759-4
- Cas Number:
- 150928-21-5
- Molecular formula:
- C18 H18 Cl I3 N2 O8
- IUPAC Name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.12
- Temp.:
- 25 °C
- pH:
- <= 7
Applicant's summary and conclusion
- Conclusions:
- log Pow = -0.12 (95 % confidence limits -0.50 - 0.27)
- Executive summary:
The n-octanol/water partition coefficient of ZK 91445 was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline no. 117) to be log Pow = -0.12 (95 % confidence limits -0.50 - 0.27) which indicates low lipophilicity. The method is based on the correlation of the reversed phaseretention data of the test compound with those of reference compounds with known log Pow values.
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