Registration Dossier
Registration Dossier
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EC number: 209-127-8 | CAS number: 556-50-3
Endpoint summary
Administrative data
Description of key information
Short-term EC50 and NOEC values for Glycyl-glycine (CAS no. 556-50-3) are available for two trophic levels of the aquatic freshwater compartment (aquatic invertebrates, algae) from GLP studies according to OECD 201 and OECD 202.
Growth inhibition study aquatic algae (Raphidocelis subcapitata) (OECD 201):
ErC50 (72h): >100 mg/l nominal concentration
NOErC (72h): 100 mg/l nominal concentration
Short term toxicity on invertebrates (Daphnia magna) (OECD 202):
EC50 (48h): >100 mg/l nominal concentration
NOEC (48h): 100 mg/l nominal concentration
Additional information
Algae
The acute toxicity of Glycyl-glycine (CAS no. 556-50-3) to the green alga Raphidocelis subcapitata was determined in a 72-hours static test according to the OECD guideline 201. The median effect concentrations (EC50) regarding growth rate and yield of Glycyl-glycine on the green alga Raphidocelis subcapitata were estimated to be >100 mg/l nominal concentration after 72 hours of exposure. The corresponding no observed effect concentrations (NOEC) were determined to be 100 mg/l nominal concentration after 72 hours of exposure. All validity criteria were fulfilled. The results of the test can be considered reliable without restriction.
Daphnia
The acute toxicity of Glycyl-glycine (CAS no. 556-50-3) to Daphnia magna was determined in a 48-hours static test according to the OECD guideline 202. The median effect concentrations (EC50) regarding immobilization of Glycyl-glycine on Daphnia magna were estimated to be >100 mg/l nominal concentration after 24 and 48 hours of exposure, respectively. The corresponding no observed effect concentrations (NOEC) were determined to be 100 mg/l nominal concentration after 24 and 48 hours of exposure, respectively. All validity criteria were fulfilled. The results of the test can be considered reliable without restriction.
Conclusion on classification
The environmental classification of Glycyl-glycine (CAS no. 556-50-3) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >100 mg/L (EC50 for algae and aquatic invertebrates). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).
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