Registration Dossier
Registration Dossier
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EC number: 815-122-7 | CAS number: 1446013-08-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14/11/2018 - 26/11/2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch n.: 160004
Appearance: White to off-white solid
Preparation: Sample prepared prior to testing for all or parts of the testing schedule (as per set guidelines, based on particle size) - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 0.651
- Temp.:
- 25 °C
- pH:
- 7.2
- Conclusions:
- Mean partition coefficient result (Log Pow): 0.651
- Executive summary:
The test is conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A.8 and OECD Test Guideline 107.
The partition coefficient is estimated from the ratio of the solubility of the test material in pure n-octanol to its solubility in water.
Three flasks are filled with the saturated solvents in the n-octanol to water ratio of 1:1, 1:2 and 2: 1 and labelled flask 1, 2 and 3 respectively. The total volume of the two-phase system selected such that it nearly fills the test vessel. Known quantities of sample are added to solvents in all three vessels, after which they are shaken vigorously with a laboratory shaker for about one hour. All three flasks are allowed to stand for over 24 hours to ensure equilibrium is reached.
The test temperature is kept constant within the range of 20 to 25°C. The pH of aqueous phase from all three test vessels is also determined. The concentration of specimen in each of the two phases, from each test vessel is determined by a suitable analytical method (e.g. HPLC, Photometric or Titration). The reliability of the determined values of Log Pow is tested by comparison of the means of the duplicate determinations with the overall mean.
Mean partition coefficient result (Log Pow): 0.651
Reference
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.651
- at the temperature of:
- 25 °C
Additional information
Mean partition coefficient result (Log Pow): 0.651
pH 7.2
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