9-Anthracenecarboxylic acid, (triethoxysilyl)methyl ester

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003-03-05 to 2003-03-13

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

only preliminary test using the flask method was performed, a main study using the column elution method was not performed because the analytical method is not sensitive enough to measure the water solubility accurately

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed, 2002-07-09

Type of method:

flask method

Specific details on test material used for the study:

- Storage condition of test material: In the freezer protected from light, under nitrogen

Water solubility:

< 2 µg/L

Conc. based on:

test mat. (dissolved fraction)

Loading of aqueous phase:

100 mg/L

Incubation duration:

>= 1 - <= 168 h

Temp.:

20.3 °C

pH:

>= 6.4 - <= 6.5

Remarks on result:

other: a main study using the column elution method was not performed because the analytical method is not sensitive enough (GC; LOQ 2 µg/L) to measure the water solubility

Preliminary test

The mean recovery of the extraction procedure was determined to be 101 % (mean of 104 %, 103 % and 97 %) and 106 % (mean of 109 % and 103 %) at a test substance concentration of 0.1 and 0.5 mg/L in water, respectively. From this it was concluded that extraction of the test substance from samples is complete when using the sample hexane ratio of 10:1 (v/v) used in this study.

In chromatograms of blank double distilled water, a small response (corresponding to 0.4 mg/L) was observed. Because this response was not observed in chromatograms of hexane and the samples, it was assumed that something had gone wrong during pre-treatment of blank double distilled water.

In chromatograms for the 1 hour, 4 hours and 7 days stirred samples, no test substance was observed. Based on this, water solubility of the test substance is reported to be smaller than the limit of detection of the analytical method used. The limit of detection was determined to be 2 µg/L taking the concentration factor of the samples (10) into account.

The pH of the supernatant after 3 centrifugation steps was 6.5, 6.5 and 6.4 for the 1 hour, 4 hours and 7 days stirred water samples, respectively.

 

Main study

A main study using the column elution method was not performed because the analytical method is not sensitive enough to measure the water solubility accurately.

In conclusion, the water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L.

Conclusions:

The water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L. The pH measured was 6.5.

Description of key information

The water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L at pH 6.5 (limitation of the analytical method).