Registration Dossier
Registration Dossier
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EC number: 250-125-1 | CAS number: 30315-46-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Title:
- Sarah Nexus 3.1
- Year:
- 2 020
- Bibliographic source:
- Sarah for windows
Materials and methods
- Principles of method if other than guideline:
- - Software tool(s) used including version:
Sarah Nexus 3.1
- Model(s) used: Sarah for Windows - Mutagenicity
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'Cross-reference' - GLP compliance:
- no
Test material
- Reference substance name:
- (S)-3-(tert-butylamino)propane-1,2-diol
- EC Number:
- 250-125-1
- EC Name:
- (S)-3-(tert-butylamino)propane-1,2-diol
- Cas Number:
- 30315-46-9
- Molecular formula:
- C7H17NO2
- IUPAC Name:
- 3-(tert-butylamino)propane-1,2-diol
- Test material form:
- solid: particulate/powder
1
Results and discussion
Test results
- Genotoxicity:
- negative
- Remarks on result:
- other: prediction
Applicant's summary and conclusion
- Conclusions:
- The query structure is predicted to be negative with 52% confidence for the 'Mutagenicity in vitro' endpoint in the model: 'Sarah Model – 2020.1 '. The compound is in the domain of the model, and supporting hypotheses containing similar examples from the training set have been found.
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