Registration Dossier
Registration Dossier
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EC number: 472-210-4 | CAS number: 41492-05-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 SEP 2005 - 21 NOV 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- Guideline 92/69/EWG 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 5.4
- Temp.:
- 25 °C
- pH:
- 7.2
- Details on results:
- 1st determination:
Calibration data:
Regresssion: log Pow = a + b log k'
Parameters: a = - 0.8791, b = 0.3412, r = 0.985
log Pow of the test substance:
1st injection: tR = 22.56 min
2nd injection: tR = 22.60 min
3rd injection: tR = 22.65 min
mean: tR = 22.603 min
k = 9.4484
logk = 0.9754
log Pow = 5.434
2nd determination:
Calibration data:
Regresssion: log Pow = a + b log k'
Parameters: a = - 0.8723, b = 0.3407, r = 0.985
log Pow of the test substance:
1st injection: tR = 22.75 min
2nd injection: tR = 22.77 min
3rd injection: tR = 22.80 min
mean: tR = 22.773 min
k = 9.5432
logk = 0.9797
log Pow = 5.436 - Conclusions:
- The log Pow was found to be 5.4.
- Executive summary:
The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in guideline 92/69/EWG, appendix A.8, following GLP. The log Pow was found to be 5.4 at a temperature of 25 °C and a pH of 7.2.
Reference
Description of key information
The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in EU Method A.8, following GLP.The log Pow was found to be 5.4.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.4
- at the temperature of:
- 25 °C
Additional information
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