ELDEW PS-203

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

weight of evidence

Study period:

09.03.1999 to 15.03.1999

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Principles of method if other than guideline:

The log Pow was calculated based on the individual solubilities of the test item in n-octanol and water and based on theoretical fragmentation, respectively.

GLP compliance:

no

Remarks:

not applicable due to the calculation of the log Pow

Type of method:

calculation method (fragments)

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Test material form:

liquid

Details on test material:

Name of test material (as cited in study report): Eldew PS-203
Physical state: pale yellow, oily liquid
Analytical purity: 100%
Purity test date: not reported
Lot/batch No.: 808010
Expiration date of the lot/batch: 31.03.2000
Storage condition of test material: test material was stored at room temperature (ca. 20°C), away from direct sunlight

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Ajinomoto Co., Inc., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 104-8315 Japan//Batch No.: 808010
- Expiration date of the lot/batch: 31.03.2000
- Purity test date: not reported

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored at room temperature at about 20°C

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

>= 23 - <= 26

Remarks on result:

not determinable because of methodological limitations

Details on results:

Neither of the available experimental test methods were applicable for the test item. Therefore, the log Pow was estimated using the calculation method based on theoretical fragmentation. Using the main components of Eldew PS-203, the log Pow was concluded to be most probably in the range between 23 to 26.

Applicant's summary and conclusion

Conclusions:

The log Pow of the test item was calculated to be in the range between 23 und 26.

Executive summary:

Neither the HPLC-method according to OECD Guideline 117 nor the flask-shaking method according to OECD 107 were applicable for the determination of the partition coefficient. The estimation of log Pow based on the individual solubilities is not reliable for substances miscible with one of the solvents in any ratio. Therefore the n-octanol/water partition coefficient log Pow was calculated via KOWWIN, Version 1.6. Based on the fragmentation of the components, log Pow values ranging from 23 to 26 were calculated via the estimation program.