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EC number: 701-200-7
CAS number: -
abnormalities were observed.
changes in body weight gain were noted.
significant increase in total serum IgE levels was noted in sensitized
rats. Measurement of specific serum IgE levels, was, however, negative.
Visual examination of
the recordings of the breathing pattern during the sensitisation phase
of animals of group A (challenge only control group) and group B (test
group) did not reveal exposure-related changes. Measurement of breathing
frequency in animals of these groups during challenge revealed a slight
decrease in breathing frequency during exposure and within one hour
after exposure, and a slight increase 48 hours after exposure, which
were, however, not different among the two groups. There were no obvious
changes in breathing pattern between animals of these groups, except for
an apnoeic breathing pattern in one animal of group B.
changes in cholinergic hyperresponsiveness upon methacholine challenge
24hafter challenge were observed.
changes in organ weights were observed.
examination at necropsy revealed enlarged mediastinal and parathymic
lymph nodes in one sensitised animal that may be related to repeated
exposure to the test compound.
inhalation of NOCOLOK flux in BN rats (sensitised animals; groups B and
C) induced histopathological changes in the nasal passages, larynx, and
lungs. Focal olfactory epithelial degeneration, necrosis and
regeneration were observed in the nasal passages. In the larynx, there
was a focal granulomatous inflammation. In the lungs, alveolar
bronchiolisation and typical alveolar macrophage accumulations were
seen. In the animals exposed singly to NOCOLOK flux (challenge only
animals; group A), a minimal granulocytic and lymphocytic/monocytic
inflammatory cell infiltrate only was seen in the larynx of a few
In addition, the
pulmonary granulomatous inflammation, which is characteristic for
(untreated) BN rats, was found in the single exposed animals (group A).
In group B and C animals, this granulomatous inflammation was less
prominent, and the cell infiltrate surrounding the terminal bronchioli
had changed from a granulocytic into a predominantly lymphocytic or
mixed granulocytic/lymphocytic infiltrate.
Animals of groups B
and C exhibited a significantly increased percentage of neutrophils and
a significantly decreased percentage ofeosinophils in bronchoalveolar
lavage fluid, which was reflected in a significantly higher absolute
number of neutrophils in animals of group B only. In animals of group C
both the absolute and relative number of lymphocytes was significantly
lower than those of the other two groups. Statistically significantly
increased levels of y-glutamyl transferase (GGT) and lactate
dehydrogenase (LDH) were observed in bronchoalveolar lavage fluid of
animals of groups B and C when compared to animals of group A.
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