Tetrakis(diethyldithiocarbamato-S,S')tellurium

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tetrakis(diethyldithiocarbamato-S,S')tellurium

EC Number:

244-121-9

EC Name:

Tetrakis(diethyldithiocarbamato-S,S')tellurium

Cas Number:

20941-65-5

Molecular formula:

C20H40N4S8Te

IUPAC Name:

N2,N2,N6,N6,N6,N6,N9,N9-octaethyl-1λ³,3,5λ³,5λ³,7,7,8λ³,10-octathia-4λ⁸-telluradispiro[3.3⁴.3⁴.3⁴]trideca-1,5,5,8-tetraene-2,6,6,9-tetramine

Test material form:

solid

Specific details on test material used for the study:

- Name of the test item (as cited in study report): Tellurium diethyldithiocarbamate
- Batch No.: MT-5D 494
- Appearance: Yellow, powder

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Froxfield Rabbits, Petersfield, Hampshire, England.
- Weight at study initiation: 2.1-3.1 kg
- Housing: individually in metal cages with perforated floors
- Diet: SQC Standard Rabbit Diet (ad libitum)
- Water: tap water (ad libitum)
- Acclimation period: 10 days

ENVIRONMENT
- Temperature: 20-21 °C
- Humidity: 45%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

24 hours prior to treatment hair was clipped from the dorso-lumbar region of each rabbit exposing an area approximately 10% of the total body surface area. The test substance was applied by spreading evenly over the clipped treatment site in as uniform a manner as possible moistened with 2.0 ml/kg bodyweight saline. The site was then covered with gauze backed with an occlusive dressing encircled firmly around the trunk of the animal. After the exposure period of 24 hours, the dressing was removed and the treatment site gently washed with water to remove any residual test substance. "Elizabethan" collars were fitted on each rabbit and were worn approximately 23 hours to prevent ingestion of any residual substance.

Duration of exposure:

24 hours

Doses:

2g/kg bodyweight

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and then at frequent intervals for the remainder of Day 1. On subsequent days the animals were observed once in the morning and once at the end of the experimental day. The following were recorded at each observation: approximate time of death of individual rabbits; nature, severity, approximate time of onset and duration of each sign of toxicity. The bodyweight of each rabbit eas recorded on Days 1, 2, 3, 5, 8, 11 and 15 or at death.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

One female rabbit was found dead on Day 12.

Clinical signs:

other: On one occasion during Day 1 (approximately 1.5 hours after dosing) one male and one female rabbit showed an abnormal (unsteady) gait. All other animals appeared normal. Signs of reaction to treatment over the following days included pilo-erection in tw

Gross pathology:

Autopsy of the dead female rabbit revealed gaseous filled stomach and intestines. Terminal autopsy revealed a diffuse minimal congestion in the lungs of one male rabbit.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met