Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- In regard to following documents, Sylibum marianum extract is considered as safe by oral route :
1) Cosmetic Ingredient Review on plant derived fatty acid oils used in cosmetics (march 4, 2011), "Oils derived from edible vegetables, fruits, seeds, and tree and ground nuts have been safely consumed by humans for millennia"
2) EFSA Journal 2012;10(5):2663, Annexe B
3) Milk Thistle (Silybum marianum) for the Therapy of Liver Disease, Kenneth Flora MD et al., American Journal of Gastroenterology volume93, pages139–143 (1998)
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
