Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 948-071-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based upon available information.
- Adequacy of study:
- key study
- Study period:
- May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information selected for the toxicokinetic assessment is primarily study data. Studies were conducted inaccordance with recognised testing guidelines.
Data source
Reference
- Reference Type:
- other: Assessment
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Results and discussion
Any other information on results incl. tables
The test material, is a substance of Unknown or Variable composition, Complex reaction products or Biological materials (UVCB) with multiple constituents. The physical state of the substanceis a liquid and therefore, potential inhalation of the substance is negligible.
The water solubility and partition coefficientof the substance could not be determined due to micelle formation in aqueous test solution and the critical micelle concentration was determined to be 363 mg/Lat 20 °C and pH 7. Quantitative structure–activity relationship (QSAR) analysis has showed that the test material are bioavailable via the oral route in accordance with Lipinski Rule Oasis. In addition, the oral LD50was estimated to be in the range of 300 – 2000 mg/kg body weight with hunched posture observed in acute oral toxicity study in female rats. In a 14-day repeated dose oral range-finding toxicity study in rats, the substance was not well tolerated at dosage levels of 500 and 1000 mg/kg/day as evidenced by moribundity, mortality, body weight losses, reduced food consumption, and/or adverse clinical observations. All rats in the 1000 mg/kg/day group were found dead or euthanized in extremis following 1 – 2 doses of the substance. In the combined repeated dose oral toxicity study with the reproductive/developmental toxicity screening test in rats,lower mean body weights, body weight gains, and food consumption were noted in adult rats receiving 250 mg/kg/day, the highest dosage level tested, but no substance-related effects were observed on reproductive performance up to the highest dosage level tested. No information is currently available on possible degradation products produced in the gastrointestinal tract.
The substance is expected to be absorbed via the dermal route and the local lymph node assay (LLNA) in mouse showed an EC3of 4.2%.
Additionally, the ready biodegradability test of the substance showed that it was not readily biodegradable. The 72-hour ErC50to freshwater green alga, 48-hour EC50toDaphnia magnaand 96-hour LC50to rainbow trout of the substance were determined to be 1.9, 6.8, and 18 mg/L, respectively, in the acute toxicity tests to aquatic organisms. The QSAR analysis has showed moderate potential for bioaccumulation in aquatic organisms.
In conclusion, based upon the available data,the substance is expected to be bioavailable but the systemic toxicity is low.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, based upon the available data,the substance is expected to be bioavailable but the systemic toxicity is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.