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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

DELTA-3-CARENE was found to be a skin sensitiser.

DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances. Therefore, DELTA-2-CARENE is classified as skin sensitiser.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances.
Reason / purpose for cross-reference:
read-across source
Key result
Reading:
1st reading
Group:
test chemical
Dose level:
10, 3 and 1%
No. with + reactions:
8
Total no. in group:
12
Clinical observations:
Minimum criterion for positive reaction: erythema
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 10, 3 and 1%. No with. + reactions: 8.0. Total no. in groups: 12.0. Clinical observations: Minimum criterion for positive reaction: erythema.
Key result
Reading:
1st reading
Group:
test chemical
Dose level:
10, 3 and 1%
No. with + reactions:
7
Total no. in group:
10
Clinical observations:
Minimum criterion for positive reaction: erythema
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 10, 3 and 1%. No with. + reactions: 7.0. Total no. in groups: 10.0. Clinical observations: Minimum criterion for positive reaction: erythema.

None

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
delta-3-Carene was found to be a skin sensitiser.

DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances. Therefore, DELTA-2-CARENE is classified as skin sensitiser.
Executive summary:

DELTA-3-CARENE was tested for skin sensitisation in female Dunkin-Hartley guinea pigs. Groups of guinea pigs (10 or 12/group) received four occluded dermal exposure for 24 hours in scapular region of 50% delta-3-carene followed by challenge dose on the shaven flanks with 10, 3, 1% and vehicle.

 

In the first set of experiments 8 out of 12 and in second, 7 out of 10 animals showed presence of erythema which was considered as positive reaction.

DELTA-3-CARENE was found to be a skin sensitiser.

DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances. Therefore, DELTA-2-CARENE is classified as skin sensitiser.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

DELTA-3-CARENE was tested for skin sensitisation in female Dunkin-Hartley guinea pigs. Groups of guinea pigs (10 or 12/group) received four occluded dermal exposure for 24 hours in scapular region of 50% delta-3-carene followed by challenge dose on the shaven flanks with 10, 3, 1% and vehicle.

 

In the first set of experiments 8 out of 12 and in second, 7 out of 10 animals showed presence of erythema which was considered as positive reaction.

DELTA-3-CARENE was found to be a skin sensitiser.

DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances. Therefore, DELTA-2-CARENE is classified as skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

As DELTA-3-CARENE showed clear signs of skin sensitisation, it is classified as skin sensitiser category 1B, H317 according to CLP Regulation (EC) N° 1272/2008 and as skin sensitiser "Xi, R43: May cause sensitisation by skin contact" according to Directive 67/548/EEC.

DELTA-3-CARENE was found to be a skin sensitiser.

DELTA-3-CARENE (source substance) and DELTA-2-CARENE (target substance) are two structurally related substances. Therefore, DELTA-2-CARENE is classified as skin sensitiser.