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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically accepted calculation method
Data source
Reference
- Reference Type:
- other: estimation software
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSAR R.6, May 2008
- Deviations:
- not applicable
- Principles of method if other than guideline:
- BCFBAF program (v 3.01): scientifically accepted calculation method for organic chemicals
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate
- Cas Number:
- 24860-22-8
- Molecular formula:
- C27H53NO2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate
- Reference substance name:
- 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate
- Cas Number:
- 85916-01-4
- Molecular formula:
- C25H49NO2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate
- Details on test material:
- The bioconcentration factors have been calculated for the two main constituents of the registered multi-constiuent substance as specified in IUCLID section 1.2.
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: fish, not further specified
Study design
- Route of exposure:
- other: not applicable
- Test type:
- other: estimated by calculation
- Water / sediment media type:
- natural water: freshwater
Test conditions
- Details on estimation of bioconcentration:
- Using BCFBAF v3.01 by US-EPA (EPIWIN) the Bioconcentration Factor (BCF) can be estimated. The following two different models are used: Regression-based estimate (traditional method), based on WSKOW and Arnot-Gobas method, based on mechanistic first principles.
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 142.2 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Result for CAS 24860-22-8
- Type:
- BCF
- Value:
- 430.8 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Result for CAS 85916-01-4
Any other information on results incl. tables
Prediction of apparent metabolism half-life in fish:
CAS 24860-22-8: 19.5 days (normalized to 10 g fish);
CAS 85916-01-4: 10.3 days (normalized to 10 g fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- scientifically accepted calculation method
- Conclusions:
- Using the EPISuite BCFBAF program, for CAS 24860-22-8 a Bioconcentration Factor (BCF) of 142.2 and log BCF = 2.153 was estimated. The biotransformation half-life was estimated to be 19.5 days (normalized to 10 g fish). The BCF for CAS 85916-01-4 was estimated to be 430.8 and log BCF = 2.634. The biotransformation half-life was estimated to be 10.3 days (normalized to 10 g fish). These values have been calculated based on an estimated LogPow of 9.81 for CAS 24860-22-8 and an estimated LogPow of 8.92 for CAS 85916-01-4. These data suggest a low potential for bioconcentration.
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