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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in chemico
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
Version / remarks:
2015
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of study:
direct peptide reactivity assay (DPRA)

Test material

Constituent 1
Test material form:
solid

In chemico test system

Details on the study design:
Skin sensitisation (In chemico test system) - Details on study design:
according to guideline

Results and discussion

Positive control results:
the positive control with cinnamaldehyde (100 mM) gave a mean depletion rate of 74.26% confirming the validity of the testsystem.

In vitro / in chemico

Resultsopen allclose all
Key result
Run / experiment:
other: 1
Parameter:
other: cystein peptide depletion
Value:
0
Vehicle controls validity:
valid
Positive controls validity:
valid
Key result
Run / experiment:
other: 2
Parameter:
other: cystein peptide depletion
Value:
0
Vehicle controls validity:
valid
Positive controls validity:
valid
Key result
Run / experiment:
other: 3
Parameter:
other: cystein peptide depletion
Value:
0
Vehicle controls validity:
valid
Positive controls validity:
valid
Key result
Run / experiment:
other: 1
Parameter:
other: lysine peptide depletion
Value:
0
Vehicle controls validity:
valid
Positive controls validity:
valid
Key result
Run / experiment:
other: 2
Parameter:
other: lysine peptide depletion
Value:
0.92
Vehicle controls validity:
valid
Positive controls validity:
valid
Key result
Run / experiment:
other: 3
Parameter:
other: lysine peptide depletion
Value:
0
Vehicle controls validity:
valid
Positive controls validity:
valid
Other effects / acceptance of results:
detailed results on peptide depletion are provided in the table attached as background material

Applicant's summary and conclusion

Interpretation of results:
other: the substance did not show peptide reactivity