2(1H)-Naphthalenone, 3,4-dihydro-5-methoxy-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 21, 2006 - July 25, 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

July 27, 1995

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

December 1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

457-080-9

EC Name:

-

Cas Number:

32940-15-1

Molecular formula:

C11H12O2

IUPAC Name:

5-methoxy-1,2,3,4-tetrahydronaphthalen-2-one

Test material form:

solid: compact

Details on test material:

- Description: White-yellowish solid

Results and discussion

Vapour pressure

Key result

Temp.:

25 °C

Vapour pressure:

0.059 Pa

Any other information on results incl. tables

Results of the experiments: 

Column	Temperature [°C]	Corrected volume at test temperature  [mL]	Amount of test item in trap 1 [μg]	Amount of test item in trap 2 [μg] (*)	Total amount trapped [μg]	Vapour pressure [Pa]
1	25	20824	74.228	< 7.886	< 82.114	5.6E-02
2	25	31723	132.599	< 7.886	< 140.485	6.2E-02
3	25	42232	248.210	< 7.886	< 256.096	8.5E-02
1	35	14895	160.371	< 7.886	< 168.257	1.6E-01
2	35	20595	248.677	< 7.886	< 256.563	1.8E-01
3	35	25624	435.709	< 7.886	< 443.595	2.5E-01
1	50	6710	505.291	< 7.886	< 513.177	1.2
2	50	9096	709.826	< 7.886	< 717.712	1.2
3	50	11460	868.135	< 7.886	< 876.021	1.2

(*)Corresponds to the lowest calibration point (3.943 μg/mL), multiplied by the dilution factor (2)

- Linear regression analysis was performed, resulting in the vapour pressure equation: ln (p)= -11325.91 x (1/T)+35.16 (r^2=0.9817; n=9)

with p=vapour pressure in Pa and T=temperature in K

- From this equation, the vapour pressure of the test item was calculated to be 0.059 Pa at 25°C (298.15 K)

- >90% of the total amount of transferred test item was determined to be collected in the first cooling trap (i.e. very good trapping efficiency)

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 25°C was determined to be 0.059 Pa.

Executive summary:

The vapour pressure of the substance was determined using the gas saturation method in a GLP study according to EC A.4 and OECD 104. A vapour pressure curve for the test item was constructed from triplicate measurements (using three different flow rates) at 25°C, 35°C and 50°C. The vapour pressure of the substance at 25°C was calculated from the curve to be 0.059 Pa.