Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 224-116-8 | CAS number: 4203-89-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: A combination of Phys-chem properties, QSAR, indirect experiments etc
- Adequacy of study:
- weight of evidence
- Reliability:
- other:
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- No true toxicokinetic, metabolism, distribution and elimination studies are available. a combination of phys-chem, QSAR properties, some animals studies and some analogue information are included
Data source
Materials and methods
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Where applicable
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No substance-specific toxicokinetic data are available. Based on the phys-chem properties and some in vivo animal studies, absorption appears to take place via the gastrointestinal route and the skin, resulting in distribution to different organs of the body and eliciting some effects. No information is available on metabolism or elimination. It is presumed that the substance will be enzymatically metabolized in liver and other organs further before elimination.
- Executive summary:
No substance-specific toxicokinetic data are available. Based on the phys-chem properties and some in vivo animal studies, absorption appears to take place via the gastrointestinal route and the skin, resulting in distribution to different organs of the body and eliciting some effects. Except the experimental hydrolysis products, no information is available on metabolism or elimination. It is presumed the substance will be enzymatically metabolized in liver and other organs further before elimination.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
