Registration Dossier
Registration Dossier
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EC number: 204-854-7 | CAS number: 127-65-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 June 2007 to 14 June 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study performed according to guideline and under GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 90.2 - <= 128 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.7 - <= 9
- Details on results:
- The analytical method (HPLC-DAD, external standard) for the determination of the test item Halamid was validated and tested with satisfactory results in regard to linearity, repeatability of injections, limit of quantification, accuracy, precision and specificity. The water solubility of the test item Halamid increased at higher temperatures. No significant pH dependence was observed. The main degradation product of Halamid, p-toluenesulfonamide was observed with a maximum concentration of 47.2 g/L (pH 5 30 ºC) corresponding to 36.6 % of the dissolved Halamid.
- Conclusions:
- very soluble (> 10000 mg/L)
The water solubility of the test item increased at higher temperatures. No significant pH dependence was observed. - Executive summary:
The water solubility in dependence of pH and temperature of Tosylchloramide sodium, trihydrate was determined according to OECD 105 EC A.6. The solubility of the test item was determined using the flask method at pH 5, 7 and 9 and at 30, 20 and 10 ± 0.5 ºC with preincubation at 35 + 0.5 ºC. The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, repeatability of injections, limit of quantification, accuracy, precision and specificity. The water solubility of the test item increased at higher temperatures. No significant pH dependence was observed. he test item was found to be very soluble (> 10000 mg/L).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- December 24, 1996
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Type of method:
- other: not specified
- Key result
- Water solubility:
- ca. 150 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 25 °C
- pH:
- ca. 7
- Remarks on result:
- other: pH assumed standard conditions
- Conclusions:
- The water solubility of the test item was determined to be ca. 150 g/L at 25 ºC.
- Executive summary:
The water solubility of the test item was determined to be ca. 150 g/L at 25 ºC.
Referenceopen allclose all
Halamid[g/L]
ºC pH 6.66 7.45 9.00
30 129 146 152
20 128 108 90.2
10 78.7 59.9 59.6
Description of key information
The watersolubility was determined to be ca. 150 g/L at 25 ºC. The substance is very soluble (>10000 mg/L).
Key value for chemical safety assessment
- Water solubility:
- 150 g/L
- at the temperature of:
- 25 °C
Additional information
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