Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 600-606-0 | CAS number: 104825-66-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One drop of a 20% solution diluted at 1/100 was instilled in the eye of 3 male Wistar rats
- GLP compliance:
- no
Test material
- Reference substance name:
- N-[2-(4-phenoxyphenoxy)ethyl]propanamide
- EC Number:
- 600-606-0
- Cas Number:
- 104825-66-3
- Molecular formula:
- C17H19NO3
- IUPAC Name:
- N-[2-(4-phenoxyphenoxy)ethyl]propanamide
- Test material form:
- solid
- Details on test material:
- Appearance: brown-beige solid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil
Constituent 1
- Specific details on test material used for the study:
- Appearance: brown-beige solid
Test item name (as cited in the report): para phenoxy phenoxy ethyl propionamid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil
Test animals / tissue source
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or tissues and environmental conditions:
- Initial weight: 300-350 g
Test system
- Vehicle:
- other: DMSO
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- One drop of a 20% (w/v) solution diluted at 1/100
- Duration of treatment / exposure:
- Not applicable
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, the test item did not show any signs of eye irritation.
- Executive summary:
One drop of a 20% (w/v) solution of test item in DMSO, diluted at 1/100, was instilled in the eye of 3 male Wistar rats. No signs of irritation were recorded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
